Chapter 1--importance of chloride homeostasis in the operation of rhythmic motor networks.

@article{Viemari2011Chapter1O,
  title={Chapter 1--importance of chloride homeostasis in the operation of rhythmic motor networks.},
  author={J C Viemari and R{\'e}mi Bos and P. Boulenguez and C{\'e}cile Brocard and Fr{\'e}d{\'e}ric Brocard and H{\'e}l{\`e}ne Bras and Patrice Coulon and Sylvie Liabeuf and Edouard Pearlstein and Karina Sadlaoud and Aur{\'e}lie Stil and Sabrina Tazerart and Laurent Vinay},
  journal={Progress in brain research},
  year={2011},
  volume={188},
  pages={3-14}
}
GABA and glycine are classically called "inhibitory" amino acids, despite the fact that their action can rapidly switch from inhibition to excitation and vice versa. The postsynaptic action depends on the intracellular concentration of chloride ions ([Cl(-)](i)), which is regulated by proteins in the plasma membrane: the K(+)-Cl(-) cotransporter KCC2 and the Na(+)-K(+)-Cl(-) cotransporter NKCC1, which extrude and intrude Cl(-) ions, respectively. A high [Cl(-)](i) leads to a depolarizing… CONTINUE READING