Chaperonins induce an amyloid-like transformation of ovine prion protein: the fundamental difference in action between eukaryotic TRiC and bacterial GroEL.

@article{Kiselev2011ChaperoninsIA,
  title={Chaperonins induce an amyloid-like transformation of ovine prion protein: the fundamental difference in action between eukaryotic TRiC and bacterial GroEL.},
  author={Georgy G Kiselev and Irina N Naletova and Evgeny V Sheval and Yulia Stroylova and Elena V Schmalhausen and Thomas Haertl{\'e} and Vladimir Muronetz},
  journal={Biochimica et biophysica acta},
  year={2011},
  volume={1814 12},
  pages={1730-8}
}
Molecular chaperones have been shown to be involved in the processes taking place during the pathogenesis of various amyloid neurodegenerative diseases. However, contradictory literature reports suggest that different molecular chaperones can either stimulate or prevent the formation of amyloid structures from distinct amyloidogenic proteins. In the present work, we concentrated on the effects caused by two molecular chaperonins, ovine TRiC and bacterial GroEL, on the aggregation and… CONTINUE READING