Chaperoning of insertion of membrane proteins into lipid bilayers by hemifluorinated surfactants: application to diphtheria toxin.

@article{Palchevskyy2006ChaperoningOI,
  title={Chaperoning of insertion of membrane proteins into lipid bilayers by hemifluorinated surfactants: application to diphtheria toxin.},
  author={Sergiy S Palchevskyy and Yevgen O. Posokhov and Blandine Olivier and J. L. Popot and Bernard Pucci and Alexey S. Ladokhin},
  journal={Biochemistry},
  year={2006},
  volume={45 8},
  pages={2629-35}
}
Hemifluorinated compounds, such as HF-TAC, make up a novel class of nondetergent surfactants designed to keep membrane proteins soluble under nondissociating conditions [Breyton, C., et al. (2004) FEBS Lett. 564, 312]. Because fluorinated and hydrogenated chains do not mix well, supramicellar concentrations of these surfactants can coexist with intact lipid vesicles. To test the ability of HF-TAC to assist proper membrane insertion of proteins, we examined its effect on the pH-triggered… CONTINUE READING
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