Chaperoning of closed syntaxin-3 through Lys46 and Glu59 in domain 1 of Munc18 proteins is indispensable for mast cell exocytosis.

@article{Bin2015ChaperoningOC,
  title={Chaperoning of closed syntaxin-3 through Lys46 and Glu59 in domain 1 of Munc18 proteins is indispensable for mast cell exocytosis.},
  author={Na-Ryum Bin and Chang Hun Jung and Byungjin Kim and Prashanth Chandrasegram and Ekaterina Turlova and Dan Zhu and Herbert Y Gaisano and Hong-Shuo Sun and Shuzo Sugita},
  journal={Journal of cell science},
  year={2015},
  volume={128 10},
  pages={1946-60}
}
Understanding how Munc18 proteins govern exocytosis is crucial because mutations of this protein cause severe secretion deficits in neuronal and immune cells. Munc18-2 has indispensable roles in the degranulation of mast cell, partly by binding and chaperoning a subset of syntaxin isoforms. However, the key syntaxin that, crucially, participates in the… CONTINUE READING