Chaperoning extended life

@article{Tatar1997ChaperoningEL,
  title={Chaperoning extended life},
  author={Marc Tatar and Aziz A. Khazaeli and James W. Curtsinger},
  journal={Nature},
  year={1997},
  volume={390},
  pages={30-30}
}
The capacity to moderate internal and external stress is arguably the central function regulating senescence in whole-animal ageing. During ageing, molecular chaperones such as heat-shock proteins are thought to combat stress-related senescent dysfunction. In transgenic Drosophila melanogaster, with varying copy numbers of the gene hsp70 encoding heat-shock protein hsp70, we found that heat-induced expression of hsp70 increased lifespan at normal temperatures. Only a brief, low level of… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
108 Citations
9 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 108 extracted citations

References

Publications referenced by this paper.
Showing 1-9 of 9 references

J. Exp. Biol

  • M E Feder, N V Cartano, L Milos, R A Krebs, S L Lindquist
  • J. Exp. Biol
  • 1997

J. Gerontol. A

  • A A Khazaeli, M Tatar, S D Pletcher, J W Curtsinger
  • J. Gerontol. A
  • 1997

BioEssays

  • G J Lithgow
  • BioEssays
  • 1996

Genetics

  • S Murakami, T E Johnson
  • Genetics
  • 1996

Science

  • S M Jazwinski
  • Science
  • 1996

Proc. Natl Acad. Sci. USA 92

  • G J Lithgow, T M White, S Melov, T E Johnson
  • Proc. Natl Acad. Sci. USA 92
  • 1995

Experientia

  • A R Heydari, T Takahashi, A Gutsmann, S You, A Richardson
  • Experientia
  • 1994

Annu. Rev. Genet

  • D A Parsell, S Lindquist
  • Annu. Rev. Genet
  • 1993

Curr. Biol

  • M A Welte, J M Tetrault, R P Dellavalle, S L Lindquist
  • Curr. Biol
  • 1993

Similar Papers

Loading similar papers…