Chaperoning extended life

  title={Chaperoning extended life},
  author={Marc Tatar and Aziz A. Khazaeli and James W. Curtsinger},
The capacity to moderate internal and external stress is arguably the central function regulating senescence in whole-animal ageing. During ageing, molecular chaperones such as heat-shock proteins are thought to combat stress-related senescent dysfunction. In transgenic Drosophila melanogaster, with varying copy numbers of the gene hsp70 encoding heat-shock protein hsp70, we found that heat-induced expression of hsp70 increased lifespan at normal temperatures. Only a brief, low level of… CONTINUE READING

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