Chaperoning Anfinsen: the steric foldases

@article{Pauwels2007ChaperoningAT,
  title={Chaperoning Anfinsen: the steric foldases},
  author={Kristof Pauwels and Inge Van Molle and Jan Tommassen and Patrick van Gelder},
  journal={Molecular Microbiology},
  year={2007},
  volume={64}
}
Some proteins are so much resistant to proteolysis and unfolding that they violate folding rules shared by the vast majority of proteins. These unusual proteins manage to fold into an active native conformation that is thermodynamically at best marginally, but often even less stable than the unfolded state. A huge energetic barrier traps these proteins kinetically in the folded state. The drawback of this situation is the need for a specialized chaperone that adds steric information to the… 
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