Chaperonin 60 and mitochondrial disease in Dictyostelium

  title={Chaperonin 60 and mitochondrial disease in Dictyostelium},
  author={Martha Kotsifas and C. Barth and Arturo De Lozanne and Sui T. Lay and Paul R Fisher},
  journal={Journal of Muscle Research & Cell Motility},
The single Dictyostelium chaperonin 60 gene, hspA, was cloned, sequenced and characterized. Sequence comparisons and a three-dimensional model for the structure of the encoded protein showed that it exhibits the conserved sequence and structural features expected for its role as the Dictyostelium mitochondrial chaperonin 60. Dictyostelium hspA contains two introns and, unusually for a member of this major heat shock gene family, is not stress-inducible in response to heat, cold or cadmium ions… CONTINUE READING


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Barchi RL (eds) The Molecular and Genetic Basis of Neurological Disease (pp. 237–269)

  • DC Wallace
  • 1997
Highly Influential
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