Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury.

@article{Giffard2004ChaperonesPA,
  title={Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury.},
  author={Rona G. Giffard and Lijun Xu and Heng Zhao and Whitney Carrico and Yibing Ouyang and Yanli Qiao and Robert Morris Sapolsky and G K Steinberg and Bingren Hu and Midori A Yenari},
  journal={The Journal of experimental biology},
  year={2004},
  volume={207 Pt 18},
  pages={3213-20}
}
Chaperones, especially the stress inducible Hsp70, have been studied for their potential to protect the brain from ischemic injury. While they protect from both global and focal ischemia in vivo and cell culture models of ischemia/reperfusion injury in vitro, the mechanism of protection is not well understood. Protein aggregation is part of the etiology of chronic neurodegenerative diseases such as Huntington's and Alzheimer's, and recent data demonstrate protein aggregates in animal models of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 86 extracted citations

Anoxia tolerant brains.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 2004
View 3 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 57 references

Susceptibility to apoptosis varies with age in cultured murine neurons and astrocytes : changes in gene expression and activity

L. Xu, V. Chock, R. G. Giffard
Neurol . Res . • 2004
View 1 Excerpt

Bcl-XL maintains mitochondrial function in murine astrocytes deprived of glucose.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 2003
View 1 Excerpt

Overexpression of HDJ-2 protects astrocytes from ischemia-like injury and reduces redistribution of ubiquitin staining in vitro.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 2003
View 7 Excerpts

Shutdown of translation: lethal or protective? Unfolded protein response versus apoptosis.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 2003

Chaperoning brain degeneration.

Proceedings of the National Academy of Sciences of the United States of America • 2002

Similar Papers

Loading similar papers…