Chaperone vermitteln die Aufnahme bakterieller AB-Toxine in Säugerzellen

@article{Ernst2017ChaperoneVD,
  title={Chaperone vermitteln die Aufnahme bakterieller AB-Toxine in S{\"a}ugerzellen},
  author={Katharina Ernst and Holger Barth},
  journal={BIOspektrum},
  year={2017},
  volume={23},
  pages={374-378}
}
Bacterial ADP-ribosylating toxins (ADP-RTs) cause severe diseases e. g. whooping cough or enterotoxicity by modifying their substrates in the cytosol leading to cellular dysfunction and clinical symptoms. We discovered that for cytosolic uptake of ADP-RTs the activity of host cell factors Hsp90, Hsp70, cyclophilins and FK506-binding proteins is required… CONTINUE READING