Chaperone overload is a possible contributor to 'civilization diseases'.

@article{Csermely2001ChaperoneOI,
  title={Chaperone overload is a possible contributor to 'civilization diseases'.},
  author={P{\'e}ter Csermely},
  journal={Trends in genetics : TIG},
  year={2001},
  volume={17 12},
  pages={701-4}
}
Molecular chaperones dampen the effect of damaging mutations that would otherwise be removed from the population by natural selection. Here, I propose that the development of modern medical practice depressed this process, leading to a rise of phenotypically silent mutations in the genome. The background of misfolded proteins increases during ageing and, by competition, prevents the chaperone-mediated buffering of silent mutations. Phenotypically exposed mutations contribute to a more-abundant… CONTINUE READING

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