Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels

  title={Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels},
  author={Gy{\"o}rgy Szabadkai and Katiuscia Bianchi and P{\'e}ter V{\'a}rnai and Diego De Stefani and Mariusz Roman Wieckowski and Dario Cavagna and A I Nagy and Tamas Balla and Rosario Rizzuto},
  journal={The Journal of Cell Biology},
  pages={901 - 911}
The voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane mediates metabolic flow, Ca(2+), and cell death signaling between the endoplasmic reticulum (ER) and mitochondrial networks. We demonstrate that VDAC1 is physically linked to the endoplasmic reticulum Ca(2+)-release channel inositol 1,4,5-trisphosphate receptor (IP(3)R) through the molecular chaperone glucose-regulated protein 75 (grp75). Functional interaction between the channels was shown by the recombinant… CONTINUE READING
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