Chaperone-mediated autophagy markers in Parkinson disease brains.

  title={Chaperone-mediated autophagy markers in Parkinson disease brains.},
  author={Lydia Alvarez-Erviti and Maria C. Rodriguez-Oroz and Jacqueline Cooper and Cristina Caballero and Isidro Ferrer and Jose A. Obeso and Anthony H V Schapira},
  journal={Archives of neurology},
  volume={67 12},
OBJECTIVE To investigate chaperone-mediated autophagy in the pathogenesis of Parkinson disease (PD). DESIGN Postmortem observational study. SETTING University Department of Clinical Neuroscience, Institute of Neurology, University College London. SUBJECTS Postmortem samples from 7 PD, 6 Alzheimer disease (AD), and 8 control brains. MAIN OUTCOME MEASURE Lysosomal-associated membrane protein 2A (LAMP2A) and heat shock cognate 70 (hsc70) protein levels were compared in the substantia nigra… CONTINUE READING
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