Chaperone-mediated autophagy and neurodegeneration: connections, mechanisms, and therapeutic implications

  title={Chaperone-mediated autophagy and neurodegeneration: connections, mechanisms, and therapeutic implications},
  author={Xiaolei Liu and Sihua Huang and Xingqin Wang and Beisha Tang and Wenming Li and Zixu Mao},
  journal={Neuroscience Bulletin},
Lysosomes degrade dysfunctional intracellular components via three pathways: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). Unlike the other two, CMA degrades cytosolic proteins with a recognized KFERQ-like motif in lysosomes and is important for cellular homeostasis. CMA activity declines with age and is altered in neurodegenerative diseases. Its impairment leads to the accumulation of aggregated proteins, some of which may be directly tied to the pathogenic processes… CONTINUE READING
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