Chaperone-mediated autophagy and neurodegeneration: connections, mechanisms, and therapeutic implications

@article{Liu2015ChaperonemediatedAA,
  title={Chaperone-mediated autophagy and neurodegeneration: connections, mechanisms, and therapeutic implications},
  author={Xiaolei Liu and Sihua Huang and Xingqin Wang and Beisha Tang and Wenming Li and Zixu Mao},
  journal={Neuroscience Bulletin},
  year={2015},
  volume={31},
  pages={407-415}
}
Lysosomes degrade dysfunctional intracellular components via three pathways: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). Unlike the other two, CMA degrades cytosolic proteins with a recognized KFERQ-like motif in lysosomes and is important for cellular homeostasis. CMA activity declines with age and is altered in neurodegenerative diseases. Its impairment leads to the accumulation of aggregated proteins, some of which may be directly tied to the pathogenic processes… CONTINUE READING
Highly Cited
This paper has 18 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 73 references

Oxidation of survival factor MEF2D in neuronal death and Parkinson's disease.

Li Gao, Hua She, +6 authors Qian Yang
Antioxidants & redox signaling • 2014
View 7 Excerpts
Highly Influenced