Chaperone-assisted protein folding: the path to discovery from a personal perspective

@article{Hartl2011ChaperoneassistedPF,
  title={Chaperone-assisted protein folding: the path to discovery from a personal perspective},
  author={F. Ulrich Hartl},
  journal={Nature Medicine},
  year={2011},
  volume={17},
  pages={1206-1210}
}
Protein folding is the process by which newly synthesized polypeptide chains acquire the three-dimensional structures necessary for biological function. For many years, protein folding was believed to occur spontaneously, on the basis of the pioneering experiments of Christian Anfinsen, who showed in the late 1950s that purified proteins can fold on their own after removal from denaturant1. Anfinsen had discovered the fundamental principle that the linear amino acid sequence holds all the… CONTINUE READING