Chaotropic ions affect the conformation of quisqualate receptors in rat cortical membranes.

@article{Honor1988ChaotropicIA,
  title={Chaotropic ions affect the conformation of quisqualate receptors in rat cortical membranes.},
  author={Tage Honor{\'e} and J. Drejer},
  journal={Journal of neurochemistry},
  year={1988},
  volume={51 2},
  pages={457-61}
}
Binding of [3H](R,S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ([3H]AMPA) to quisqualate receptors in the presence of SCN- ions produced curvilinear Scatchard plots. Kinetic investigations of [3H]AMPA binding showed that the curvilinearity cannot be explained by assuming binding to two separate binding sites or by considering it due to cooperative interaction. A more likely explanation is that the quisqualate receptors exist in two states, one with high and one with low affinity… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

Phosphonate quinoxalinedione AMPA antagonists.

Restorative neurology and neuroscience • 2000
View 1 Excerpt

Similar Papers

Loading similar papers…