Channels formed by subnanomolar concentrations of the toxin aerolysin trigger apoptosis of T lymphomas.

@article{Nelson1999ChannelsFB,
  title={Channels formed by subnanomolar concentrations of the toxin aerolysin trigger apoptosis of T lymphomas.},
  author={Kathryn L Nelson and Robert A Brodsky and J. Thomas Buckley},
  journal={Cellular microbiology},
  year={1999},
  volume={1 1},
  pages={69-74}
}
Aerolysin is a channel-forming toxin that binds to glycosylphosphatidylinositol (GPI)-anchored proteins, such as Thy-1, on target cells. Here, we show that subnanomolar concentrations of aerolysin trigger apoptosis of T lymphomas. Using inactive aerolysin variants, we determined that apoptosis was not directly triggered by binding to GPI-anchored receptors, nor was it caused by receptor clustering induced by toxin oligomerization. Apoptosis was caused by the production of a small number of… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

Vip3Aa induces apoptosis in cultured Spodoptera frugiperda (Sf9) cells.

Toxicon : official journal of the International Society on Toxinology • 2016
View 2 Excerpts

Similar Papers

Loading similar papers…