Channels formed by botulinum, tetanus, and diphtheria toxins in planar lipid bilayers: relevance to translocation of proteins across membranes.

@article{Hoch1985ChannelsFB,
  title={Channels formed by botulinum, tetanus, and diphtheria toxins in planar lipid bilayers: relevance to translocation of proteins across membranes.},
  author={D H Hoch and M Romero-Mira and Barbara E Ehrlich and Ann Finkelstein and Bibhuti R Dasgupta and Lance L. Simpson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1985},
  volume={82 6},
  pages={1692-6}
}
The heavy chains of both botulinum neurotoxin type B and tetanus toxin form channels in planar bilayer membranes. These channels have pH-dependent and voltage-dependent properties that are remarkably similar to those previously described for diphtheria toxin. Selectivity experiments with anions and cations show that the channels formed by the heavy chains of all three toxins are large; thus, these channels could serve as "tunnel proteins" for translocation of active peptide fragments. These… CONTINUE READING

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