Channelopathies from mutations in the cardiac sodium channel protein complex.

  title={Channelopathies from mutations in the cardiac sodium channel protein complex.},
  author={Graham S Adsit and Ravi Vaidyanathan and Carla M Galler and John W. Kyle and Jonathan C. Makielski},
  journal={Journal of molecular and cellular cardiology},
The cardiac sodium current underlies excitability in heart, and inherited abnormalities of the proteins regulating and conducting this current cause inherited arrhythmia syndromes. This review focuses on inherited mutations in non-pore forming proteins of sodium channel complexes that cause cardiac arrhythmia, and the deduced mechanisms by which they affect function and dysfunction of the cardiac sodium current. Defining the structure and function of these complexes and how they are regulated… CONTINUE READING
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