Channelopathies: a New Category of Diseases Causing Sudden Death

  title={Channelopathies: a New Category of Diseases Causing Sudden Death},
  author={J. Brugada and R. Brugada and P. Brugada},
  journal={Herz Kardiovaskul{\"a}re Erkrankungen},
  • J. Brugada, R. Brugada, P. Brugada
  • Published 2007
  • Medicine
  • Herz Kardiovaskuläre Erkrankungen
  • Identification of familial forms of different diseases has provided a unique opportunity to study how changes in the structure of a gene create a dysfunction in the physiology of the resulting protein. Changes in the genes encoding for ion channels produce modifications in the function of the channel. Changes in the sodium channel are responsible for long QT syndrome, Brugada syndrome and conduction defects. Changes in the potassium channels have been related to long QT syndrome, short QT… CONTINUE READING
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    Publications referenced by this paper.
    Short QT syndrome
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    Genetic and biophysical basis of sudden unexplained nocturnal death syndrome (SUNDS), a disease allelic to Brugada syndrome.
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