Channeling by Proximity: The Catalytic Advantages of Active Site Colocalization Using Brownian Dynamics

@inproceedings{Bauler2010ChannelingBP,
  title={Channeling by Proximity: The Catalytic Advantages of Active Site Colocalization Using Brownian Dynamics},
  author={Patricia Bauler and Gary A. Huber and Thomas S. Leyh and James Andrew McCammon},
  booktitle={The journal of physical chemistry letters},
  year={2010}
}
Nature often colocalizes successive steps in a metabolic pathway. Such organization is predicted to increase the effective concentration of pathway intermediates near their recipient active sites and to enhance catalytic efficiency. Here, the pathway of a two-step reaction is modeled using a simple spherical approximation for the enzymes and substrate… CONTINUE READING

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