Channel regulation of glucose sensing in the pancreatic beta-cell.

  title={Channel regulation of glucose sensing in the pancreatic beta-cell.},
  author={Marcia Hiriart and Lydia Aguilar-Bryan},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={295 6},
Mammalian beta-cells are acutely and chronically regulated by sensing surrounding glucose levels that determine the rate at which insulin is secreted, to maintain euglycemia. Experimental research in vitro and in vivo has shown that, when these cells are exposed to adverse conditions like long periods of hypoglycemia or hyperglycemia, their capability to sense glucose is decreased. Understanding the normal physiology and identifying the main players along this route becomes paramount. In this… CONTINUE READING

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Characterization of a Ca2+ release 40 activated nonselective cation current regulating membrane potential and [Ca]i oscillations in transgenically derived beta-cells

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