Channel opening by anesthetics and GABA induces similar changes in the GABAA receptor M2 segment.

@article{Rosen2007ChannelOB,
  title={Channel opening by anesthetics and GABA induces similar changes in the GABAA receptor M2 segment.},
  author={Ayelet Rosen and Moez Bali and Jeffrey Horenstein and Myles H. Akabas},
  journal={Biophysical journal},
  year={2007},
  volume={92 9},
  pages={3130-9}
}
For many general anesthetics, their molecular basis of action involves interactions with GABA(A) receptors. Anesthetics produce concentration-dependent effects on GABA(A) receptors. Low concentrations potentiate submaximal GABA-induced currents. Higher concentrations directly activate the receptors. Functional effects of anesthetics have been characterized, but little is known about the conformational changes they induce. We probed anesthetic-induced conformational changes in the M2 membrane… CONTINUE READING