Channel-mediated lactate release by K⁺-stimulated astrocytes.


Excitatory synaptic transmission is accompanied by a local surge in interstitial lactate that occurs despite adequate oxygen availability, a puzzling phenomenon termed aerobic glycolysis. In addition to its role as an energy substrate, recent studies have shown that lactate modulates neuronal excitability acting through various targets, including NMDA… (More)
DOI: 10.1523/JNEUROSCI.5036-14.2015

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