Channel-forming toxins: tales of transformation.

  • Eric Gouaux
  • Published 1997 in Current opinion in structural biology

Abstract

Channel-forming bacterial toxins undergo a series of remarkable changes in solubility, oligomerization state, structure and dynamics during the processes of membrane binding, assembly, membrane insertion and channel formation. Recent high-resolution crystal structures of channel-forming toxins, in both water-soluble and membrane-bound, channel-formed states… (More)

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