Channel beta2-4 subunits fail to substitute for beta1 in sensitizing BK channels to lithocholate.

  title={Channel beta2-4 subunits fail to substitute for beta1 in sensitizing BK channels to lithocholate.},
  author={Anna N Bukiya and Thirumalini Vaithianathan and Ligia Toro and Alex M Dopico},
  journal={Biochemical and biophysical research communications},
  volume={390 3},
Large conductance, calcium- and voltage-gated potassium (BK) channels regulate numerous physiological processes. While most basic functional characteristics of native BK channels are reproduced by BK alpha (slo1) subunit homotetramers, key biophysical and pharmacological properties are drastically modified by the presence of auxiliary beta subunits (encoded by KCNMB1-4). Numerous physiological steroids, including sex hormones, gluco- and mineralocorticoids, activate beta subunit-containing BK… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 12 extracted citations

Calcium- and voltage-gated BK channels in vascular smooth muscle

Pflügers Archiv - European Journal of Physiology • 2018
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 50 references


R. Behrens, A. Nolting
Reimann, et al., hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel b subunit family, FEBS Lett 474 (2000) 99–106. 1000 A.N. Bukiya et al. / Biochemical and Biophysical Research Communications 390 • 2009
View 4 Excerpts
Highly Influenced


J. Lippiat, N. Standen
Harrow, et al., Properties of BK(Ca) channels formed by bicistronic expression of hSloalpha and beta1-4 subunits in HEK293 cells, J. Membr. Biol. 192 (2) • 2003
View 3 Excerpts
Highly Influenced


M. Thomsen, C. Wang
Ozgen, et al., Accessory subunit KChIP2 modulates the cardiac L-type calcium current, Circ. Res. 104 (12) • 2009


T. Vaithianathan, A. Bukiya
Liu, et al., Direct regulation of BK channels by phosphatidylinositol 4,5-bisphosphate as a novel signaling pathway, J. Gen. Physiol. 132 (1) • 2008

Similar Papers

Loading similar papers…