Channel beta2-4 subunits fail to substitute for beta1 in sensitizing BK channels to lithocholate.

@article{Bukiya2009ChannelBS,
  title={Channel beta2-4 subunits fail to substitute for beta1 in sensitizing BK channels to lithocholate.},
  author={Anna N Bukiya and Thirumalini Vaithianathan and Ligia Toro and Alex M Dopico},
  journal={Biochemical and biophysical research communications},
  year={2009},
  volume={390 3},
  pages={995-1000}
}
Large conductance, calcium- and voltage-gated potassium (BK) channels regulate numerous physiological processes. While most basic functional characteristics of native BK channels are reproduced by BK alpha (slo1) subunit homotetramers, key biophysical and pharmacological properties are drastically modified by the presence of auxiliary beta subunits (encoded by KCNMB1-4). Numerous physiological steroids, including sex hormones, gluco- and mineralocorticoids, activate beta subunit-containing BK… CONTINUE READING

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