Channel Openings Are Necessary but not Sufficient for Use-dependent Block of Cardiac Na+ Channels by Flecainide

  title={Channel Openings Are Necessary but not Sufficient for Use-dependent Block of Cardiac Na+ Channels by Flecainide},
  author={Huajun Liu and Michihiro Tateyama and Colleen E. Clancy and H. Abriel and Robert S. Kass},
  journal={The Journal of General Physiology},
  pages={39 - 51}
Na(+) channel blockers such as flecainide have found renewed usefulness in the diagnosis and treatment of two clinical syndromes arising from inherited mutations in SCN5A, the gene encoding the alpha subunit of the cardiac voltage-gated Na(+) channel. The Brugada syndrome (BrS) and the LQT-3 variant of the Long QT syndrome are caused by disease-linked SCN5A mutations that act to change functional and pharmacological properties of the channel. Here we have explored a set of SCN5A mutations… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 33 extracted citations

The cardiac persistent sodium current: an appealing therapeutic target?

British journal of pharmacology • 2008
View 4 Excerpts
Highly Influenced

Flecainide sensitivity of a Na channel long QT mutation shows an open-channel blocking mechanism for use-dependent block.

American journal of physiology. Heart and circulatory physiology • 2006
View 4 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 40 references

Kinetic analysis of phasic inhibition of neuronal sodium currents by lidocaine and bupivacaine

G. R. Strichartz
Biophys . J . • 1990
View 3 Excerpts
Highly Influenced

Normalization of ventricular repolarization with flecainide in long QT syndrome patients with SCN5A:DeltaKPQ mutation.

Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc • 2001

Novel ar - rhythmogenic mechanism revealed by a long - qt syndrome mutation in the cardiac na (  ) channel

J. Benhorin, B. Kerem, R. S. Kass
Circ . Res . • 2001

[Long QT syndrome and Brugada syndrome: 2 aspects of the same disease?].

Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology • 2001

Similar Papers

Loading similar papers…