Changing the landscape for type 1 diabetes: the first step to prevention
@article{Dayan2019ChangingTL, title={Changing the landscape for type 1 diabetes: the first step to prevention}, author={Colin M. Dayan and Mariam P. Korah and Danijela Tatovi{\'c} and Brian N. Bundy and Kevan C. Herold}, journal={The Lancet}, year={2019}, volume={394}, pages={1286-1296} }
31 Citations
Immunotherapy for type 1 diabetes.
- MedicineBritish medical bulletin
- 2021
A consensus on how to identify individuals who may benefit from immunotherapy to prevent disease onset is needed, and the development of optimal strategies for preventing and delaying progression of type 1 diabetes, and monitoring the response to immunointervention are needed.
Insulin is necessary but not sufficient: changing the therapeutic paradigm in type 1 diabetes
- MedicineF1000Research
- 2020
The history and current status of immunotherapy for T1D is outlined, and the activities of Diabetes TrialNet, a National Institutes of Health consortium launched in 2004, are focused on.
Type 1 diabetes mellitus: much progress, many opportunities.
- Medicine, BiologyThe Journal of clinical investigation
- 2021
It is now clear that there is considerable heterogeneity in T1D with regards to genetics, pathology, response to immune-based therapies, clinical course, and susceptibility to diabetes-related complications.
Replacing insulin with immunotherapy: Time for a paradigm change in Type 1 diabetes
- Medicine, BiologyDiabetic medicine : a journal of the British Diabetic Association
- 2021
Type 1 diabetes scientific community has a challenging task ahead—to fundamentally change the management of this devastating disease by using low‐risk immunotherapy to preserve endogenous beta‐cell function and make metabolic control substantially easier.
CTLA4-Ig (abatacept): a promising investigational drug for use in type 1 diabetes
- Medicine, BiologyExpert opinion on investigational drugs
- 2020
The pharmacokinetic parameters and pharmacodynamic markers of abatacept are shown in vivo and in clinical trials, guiding dosage regimen recommendations for future investigational studies and expert opinion Immunomodulation is one of the promising strategies for decelerating the progression of beta-cell destruction after the onset of T1D.
Pathogenesis of Type 1 Diabetes: Established Facts and New Insights
- Biology, MedicineGenes
- 2022
The interplay between genetic predisposition and other non-genetic factors, such as viral infections, diet, and gut biome, which all potentially contribute to the aetiology of T1D are highlighted.
Type 1 diabetes mellitus and its oral tolerance therapy
- Medicine, BiologyWorld journal of diabetes
- 2020
A current overview of oral tolerance therapy for T1DM conducted in both animal models and clinical trials is given, acting as an antigen-specific immunotherapy for type 1 diabetes mellitus.
Apolipoprotein CIII Is an Important Piece in the Type-1 Diabetes Jigsaw Puzzle
- Biology, MedicineInternational journal of molecular sciences
- 2021
The findings that apolipoprotein CIII (apoCIII) is increased in T1D and that in vitro studies revealed that healthy β-cells exposed to apoCIII became apoptotic are summarized to highlight the need for exploring this field as the authors still are only seeing the top of the iceberg.
Gastrointestinal Microbiota and Type 1 Diabetes Mellitus: The State of Art
- Medicine, BiologyJournal of clinical medicine
- 2019
Available data on the associations between gut microbiota and T1DM in both experimental animals and humans are summarized and future perspectives in this novel and exciting area of research are discussed.
Advanced Approaches in Immunotherapy for the Treatment of Type 1 Diabetes Mellitus
- Biology, Medicine
- 2020
An ever-evolving field of immunology has shifted the paradigm of how T1DM is understood, and the repurposing of T-cellbased biotechnology has the potential to change the way that it is treated.
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