Changing the chemokine gradient: CINC1 crosses the blood–brain barrier

  title={Changing the chemokine gradient: CINC1 crosses the blood–brain barrier},
  author={Weihong Pan and Abba J. Kastin},
  journal={Journal of Neuroimmunology},
Chemokines are a large family of small, inducible, secreted, chemoattractant cytokines that are involved in inflammatory processes. It is well known that systemic and CNS infections cause disruption of the blood-brain barrier (BBB); however, it is not clear how chemokines are involved in this process. We studied the pharmacokinetics of the passage of the chemokine cytokine-induced neutrophil chemoattractant-1 (CINC1) from blood to brain after i.v. bolus injection and its efflux out of the brain… CONTINUE READING

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