Changing the adenovirus fiber for retaining gene delivery efficacy in the presence of neutralizing antibodies

@article{Srkioja2008ChangingTA,
  title={Changing the adenovirus fiber for retaining gene delivery efficacy in the presence of neutralizing antibodies},
  author={Merja S{\"a}rkioja and Sari Pesonen and Mari Raki and Tanja Hakkarainen and Jarmo Salo and Marko T. Ahonen and Anna Kanerva and Akseli Hemminki},
  journal={Gene Therapy},
  year={2008},
  volume={15},
  pages={921-929}
}
Prior infection has primed most adult humans for a rapid neutralizing antibody (NAb) response when re-exposed to adenovirus. NAb induction can severely limit the efficacy of systemic re-administration of adenoviral gene therapy. We hypothesized that changing the fiber knob could overcome NAb. Immune-competent mice were exposed to serotype 5 adenovirus (Ad5)(GL), Ad5/3luc1, Ad5lucRGD or Ad5pK7(GL). Mice immunized with Ad5(GL) featured reduced intravenous Ad5(GL) gene transfer to most organs… CONTINUE READING