Changing the Receptor Specificity of Anthrax Toxin

  title={Changing the Receptor Specificity of Anthrax Toxin},
  author={Adva Mechaly and Andrew J. McCluskey and Robert J. Collier},
UNLABELLED The actions of many bacterial toxins depend on their ability to bind to one or more cell-surface receptors. Anthrax toxin acts by a sequence of events that begins when the protective-antigen (PA) moiety of the toxin binds to either one of two cell-surface proteins, ANTXR1 and ANTXR2, and is proteolytically activated. The activated PA self-associates to form oligomeric pore precursors, which, in turn, bind the enzymatic moieties of the toxin and transport them to the cytosol. We… CONTINUE READING


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Three-dimensional structure of the anthrax toxin pore inserted into lipid nanodiscs and lipid vesicles

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