Changing prognostic significance of tumor stage and nodal stage in patients with squamous cell carcinoma of the oropharynx in the human papillomavirus era

  title={Changing prognostic significance of tumor stage and nodal stage in patients with squamous cell carcinoma of the oropharynx in the human papillomavirus era},
  author={Florence K. Keane and Yui‐Hui Chen and Bridget A. Neville and Roy B Tishler and Jonathan D. Schoenfeld and Paul J. Catalano and Danielle N Margalit},
Although human papillomavirus (HPV)–associated oropharyngeal squamous cell carcinoma (OPSCC) tends to present at an advanced nodal stage (N stage), the prognosis is generally better than that for HPV‐negative OPSCC. Prior work has demonstrated the increasing incidence of HPV‐related OPSCC in the United States. This study was designed to determine whether the changing epidemiology of OPSCC is reflected in changes in the prognostic significance of the tumor stage (T stage) and the N stage in a… 

Refining prognostic stratification of human papillomavirus-related oropharyngeal squamous cell carcinoma: different prognosis between T1 and T2

The 8th AJCC/UICC TNM staging system did not clearly distinguish the prognosis of stage II from that of other stages, and including the T2N0-1 group in stage II may improve prognostic stratification.

Prognostic value of the lymph node ratio in oropharyngeal carcinoma stratified for HPV-status

The LNR with a cut-off value of 10% serves as an additional prognostic parameter in HPV-related OPSCC and may help to improve risk stratification in combination with the revised AJCC 8th edition TNM classification.

Carcinoma of Unknown Primary and the 8th Edition TNM Classification for Head and Neck Cancer

The aim of this study was to investigate the influence of the new classification on the prognosis of p16‐positive and p16-negative CUP and the impact of EBV proof.

Special Issue about Head and Neck Cancers: HPV Positive Cancers

De-intensification strategies are being evaluated in ongoing clinical trials and if validated, might help spare severe morbidity associated with current cisplatin-based chemoradiotherapy, which is the standard of care for all patients with locally advanced head and neck cancer.

Pathology-based staging for HPV-positive squamous carcinoma of the oropharynx.

Prognostic Impact of AJCC/UICC 8th Edition New Staging Rules in Oropharyngeal Squamous Cell Carcinoma

While the 7th edition of UICC shows invalid discrimination between stages, the 8th edition is more suitable for HPV-associated carcinoma and further adaption is essential.

Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma Demographics , Prognosis , and Staging

The shifting demographics of HPV infection as they relate to OPSCC incidence is reviewed, the data suggesting improved outcomes in HPV+ OPSCC is outlined, and current efforts to develop a new staging system for HPV+OPSCC patients are highlighted.

Update on oral and oropharyngeal cancer staging – International perspectives




Patterns of nodal metastasis and prognosis in human papillomavirus–positive oropharyngeal squamous cell carcinoma

The purpose of this study was to develop a system that more precisely predicts survival in patients with human papillomavirus‐positive oropharyngeal squamous cell carcinoma.

Human papillomavirus modifies the prognostic significance of T stage and possibly N stage in tonsillar cancer.

  • A. HongA. Martín B. Rose
  • Medicine, Biology
    Annals of oncology : official journal of the European Society for Medical Oncology
  • 2013
The prognostic significance of the conventional staging system in tonsillar cancer is modified by HPV, and after adjusting for age, gender and treatment, T stage appeared relevant only for HPV-positive cancers.

Human papillomavirus and survival of patients with oropharyngeal cancer.

Tumor HPV status is a strong and independent prognostic factor for survival among patients with oropharyngeal cancer and the risk of death significantly increased with each additional pack-year of tobacco smoking.

High-risk human papillomavirus affects prognosis in patients with surgically treated oropharyngeal squamous cell carcinoma.

  • L. LicitraF. Perrone S. Pilotti
  • Medicine, Biology
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2006
The molecular and clinical results are in agreement with previous findings but provide additional information into the biologic mechanisms involved in HR-HPV oropharyngeal cancer in comparison to HPV-negative tumors.

Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial.

For patients with HNSCC of the oropharynx, tumor HPV status is strongly associated with therapeutic response and survival and, after adjustment for age, tumor stage, and ECOG performance status, lower risks of progression and death are found.

Prognostic factors and survival unique to surgically treated p16+ oropharyngeal cancer

It is feasible to conduct a detailed appraisal based on pathologic information from surgical specimens of both the primary and neck, to establish prognosticators unique to p16+ oropharynx cancer patients.

Cystic lymph node metastasis in patients with head and neck cancer: An HPV‐associated phenomenon

The clinical and virologic associations of cystic nodal metastasis in head and neck cancer (HNSCC) were investigated and cystic lymph node metastases were associated with tonsil cancer.

Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States.

The proportion of OSCCs that are potentially HPV-related increased in the United States from 1973 to 2004, perhaps as a result of changing sexual behaviors.

Human Papillomavirus and Cystic Node Metastasis in Oropharyngeal Cancer and Cancer of Unknown Primary Origin

HPV status remains unchanged after metastasis, including the presence of HPV DNA, genotype, and physical status, as well as the expression pattern of p16 were consistent between node metastasis and primary or occult primary tumor.