Changing numbers of neuronal and non-neuronal cells underlie postnatal brain growth in the rat

  title={Changing numbers of neuronal and non-neuronal cells underlie postnatal brain growth in the rat},
  author={F. Bandeira and R. Lent and S. Herculano-Houzel},
  journal={Proceedings of the National Academy of Sciences},
  pages={14108 - 14113}
  • F. Bandeira, R. Lent, S. Herculano-Houzel
  • Published 2009
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • The rat brain increases >6× in mass from birth to adulthood, presumably through the addition of glial cells and increasing neuronal size, without the addition of neurons. To test this hypothesis, here we investigate quantitatively the postnatal changes in the total number of neuronal and non-neuronal cells in the developing rat brain, and examine how these changes correlate with brain growth. Total numbers of cells were determined with the isotropic fractionator in the brains of 53 Wistar rats… CONTINUE READING
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