Changing glucocorticoid action: 11β-Hydroxysteroid dehydrogenase type 1 in acute and chronic inflammation

@inproceedings{Chapman2013ChangingGA,
  title={Changing glucocorticoid action: 11β-Hydroxysteroid dehydrogenase type 1 in acute and chronic inflammation},
  author={Karen E. Chapman and Agnes E. Coutinho and Zhenguang Zhang and Tiina M. J. Kipari and John Savill and Jonathan R Seckl},
  booktitle={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2013}
}
Since the discovery of cortisone in the 1940s and its early success in treatment of rheumatoid arthritis, glucocorticoids have remained the mainstay of anti-inflammatory therapies. However, cortisone itself is intrinsically inert. To be effective, it requires conversion to cortisol, the active glucocorticoid, by the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). Despite the identification of 11β-HSD in liver in 1953 (which we now know to be 11β-HSD1), its physiological role has been… CONTINUE READING
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