Changing expression and subcellular distribution of karyopherins during murine oogenesis.

@article{Mihalas2015ChangingEA,
  title={Changing expression and subcellular distribution of karyopherins during murine oogenesis.},
  author={Bettina P Mihalas and Patrick S Western and Kate L Loveland and Eileen A McLaughlin and Janet E. Holt},
  journal={Reproduction},
  year={2015},
  volume={150 6},
  pages={485-96}
}
Mammalian oocyte growth and development is driven by a strict program of gene expression that relies on the timely presence of transcriptional regulators via nuclear pores. By targeting specific cargos for nucleo-cytoplasmic transport, karyopherin (KPN) proteins are key to the relocation of essential transcription factors and chromatin-remodelling factors into and out of the nucleus. Using multiple complementary techniques, here we establish that KPNA genes and proteins are dynamically… CONTINUE READING

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1 Excerpt

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