Changing body temperature affects the T2* signal in the rat brain and reveals hypothalamic activity.

@article{Vanhoutte2006ChangingBT,
  title={Changing body temperature affects the T2* signal in the rat brain and reveals hypothalamic activity.},
  author={Greetje Vanhoutte and Marleen Verhoye and Alexander M. van der Linden},
  journal={Magnetic resonance in medicine},
  year={2006},
  volume={55 5},
  pages={1006-12}
}
This study was designed to determine brain activity in the hypothalamus-in particular the thermoregulatory function of the hypothalamic preoptic area (PO). We experimentally changed the body temperature in rats within the physiological range (37-39 degrees C) and monitored changes in blood oxygenation level-dependent (BOLD) MR signal. To explore PO activity we had to deal with general signal changes caused by temperature-dependent alterations in the affinity of oxygen for hemoglobin, which… CONTINUE READING
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