Changing a limb muscle growth program into a resorption program.

  title={Changing a limb muscle growth program into a resorption program.},
  author={Liquan Cai and Biswajit Das and Donald D. Brown},
  journal={Developmental biology},
  volume={304 1},
Transgenic Xenopus laevis tadpoles that express a dominant negative form of the thyroid hormone receptor (TRDN) controlled by the cardiac actin muscle promoter (pCar) develop with very little limb muscle. Under the control of the tetracycline system the transgene can be induced at will by adding doxycycline to the rearing water. Pre-existing limb muscle fibers begins to disintegrate within 2 days after up-regulation of the TRDN transgene. The muscle cells do not die even after weeks of… CONTINUE READING