Changing Expression of Cyclooxygenases and Prostaglandin Receptor EP4 During Development of the Human Ductus Arteriosus

@article{Rheinlaender2006ChangingEO,
  title={Changing Expression of Cyclooxygenases and Prostaglandin Receptor EP4 During Development of the Human Ductus Arteriosus},
  author={Cornelia Rheinlaender and Sven Weber and Nanette M E Sarioglu and Evelyn Strauss and Michael Obladen and Petra S Koehne},
  journal={Pediatric Research},
  year={2006},
  volume={60},
  pages={270-275}
}
Programmed proliferative degeneration of the human fetal ductus arteriosus (DA) in preparation for its definite postnatal closure has a large developmental variability and is controlled by several signaling pathways, most prominently by prostaglandin (PG) metabolism. Numerous studies in various mammalian species have shown interspecies and developmental differences in ductal protein expression of cyclooxygenase (COX) isoforms and PG E receptor subtypes (EP1-4). We examined COX1, COX2, and EP4… CONTINUE READING

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