Changes on 5-HT2 receptor mRNAs in striatum and subthalamic nucleus in Parkinson's disease model.

@article{Zhang2007ChangesO5,
  title={Changes on 5-HT2 receptor mRNAs in striatum and subthalamic nucleus in Parkinson's disease model.},
  author={Xiaoqun Zhang and Per E. Andr{\'e}n and Per Svenningsson},
  journal={Physiology & behavior},
  year={2007},
  volume={92 1-2},
  pages={29-33}
}
Abnormal interactions between the serotonin and dopamine systems may underlie the high prevalence of non-motor complications in Parkinson's disease (PD). Here, we demonstrate that the genes encoding serotonin 5-HT2A and 5-HT2C receptors are differently regulated by dopamine in the 6-hydroxydopamine (6-OHDA) rat model of PD. Nigrostriatal cell loss causes an up-regulation of 5-HT2AR mRNA, but a down-regulation of 5-HT2CR mRNA, in striatum. Repeated injections with L-DOPA/benserazide reverse the… CONTINUE READING