[Changes of telomere length in human nasopharyngeal carcinoma].


Using Southern hybridization, we analysed the telomere length from thirty patients with nasopharyngeal carcinoma and demonstrated telomere reduction in these individuals when compared with their age-matched controls. Of the 30 samples, 16.67% had telomere elongation, 76.67% had telomere reduction and 6.67% exhibited equal lengths as compared with the controls. Analysis of leukocytes from 30 controls indicated that the telomere length decreased (average 39 base Pairs Per year) with aging and a statistically significant correlation between the length and age was noted (r = -0.3913, P < 0.05). These results suggest that the consequences of telomere shortening in nasopharyngeal carcinoma may lead to chromosome instability.

Cite this paper

@article{Xiao1999ChangesOT, title={[Changes of telomere length in human nasopharyngeal carcinoma].}, author={Lihua Xiao and H Zhou and Jing Yan and Y Liu and You Song}, journal={Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao}, year={1999}, volume={30 3}, pages={262-4} }