Changes of sphingolipid species in the phenotype conversion from myofibroblasts to lipocytes in hepatic stellate cells.

@article{Andrade2003ChangesOS,
  title={Changes of sphingolipid species in the phenotype conversion from myofibroblasts to lipocytes in hepatic stellate cells.},
  author={Cl{\'a}udia M. B. Andrade and Vera Maria Treis Trindade and Carla C.A. Cardoso and Ana Luiza Ziulkoski and Luiz Carlos Trugo and Regina Maria Guaragna and Radovan Borojevi{\'c} and F{\'a}tima Teresinha Costa Rodrigues Guma},
  journal={Journal of cellular biochemistry},
  year={2003},
  volume={88 3},
  pages={
          533-44
        }
}
Sphingolipids play a relevant role in cell-cell interaction, communication, and migration. We studied the sphingolipid content in the murine hepatic stellate cell line GRX, which expresses the myofibroblast phenotype, and can be induced in vitro to display the fat-storing phenotype. Lipid modifications along this induction were investigated by labeling sphingolipids with [(14)C]galactose, [(14)C]serine, or [(14)C]choline, and determination of fatty acid composition of sphingomyelin. The total… CONTINUE READING

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