Changes of sodium channel expression in experimental painful diabetic neuropathy.

@article{Craner2002ChangesOS,
  title={Changes of sodium channel expression in experimental painful diabetic neuropathy.},
  author={Matthew J. Craner and Joshua P. Klein and Muthukrishnan Renganathan and J Andrew Black and Stephen G. Waxman},
  journal={Annals of neurology},
  year={2002},
  volume={52 6},
  pages={786-92}
}
Although pain is experienced by many patients with diabetic neuropathy, the pathophysiology of painful diabetic neuropathy is not understood. Substantial evidence indicates that dysregulated sodium channel gene transcription contributes to hyperexcitability of dorsal root ganglion neurons, which may produce neuropathic pain after axonal transection. In this study, we examined sodium channel mRNA and protein expression in dorsal root ganglion neurons in rats with streptozotocin-induced diabetes… CONTINUE READING

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