Changes of serum sICAM-1 and MMP-9 induced by rIFNbeta-1b treatment in relapsing-remitting MS.

@article{Trojano1999ChangesOS,
  title={Changes of serum sICAM-1 and MMP-9 induced by rIFNbeta-1b treatment in relapsing-remitting MS.},
  author={Maria Trojano and Carlo Avolio and Grazia Maria Liuzzi and Maddalena Ruggieri and Giovanni Defazio and Maria Liguori and Maria Pia Santacroce and Damiano Paolicelli and Fabrizio Giuliani and Paolo Riccio and Paolo Livrea},
  journal={Neurology},
  year={1999},
  volume={53 7},
  pages={1402-8}
}
OBJECTIVE To correlate changes in serum levels of intercellular adhesion molecule-1 (sICAM-1) and matrix metalloproteinases (MMP) with clinical and MRI evidence of disease activity in MS patients receiving treatment with interferon-beta (rIFNbeta)-1b. BACKGROUND rIFNbeta reduces the frequency of gadolinium-enhancing (Gd+) MRI in relapsing-remitting MS (RRMS). Its mechanism of action on improving the integrity of the blood-brain barrier remains unclear. METHODS sICAM-1 and MMP-9 and MMP-2… CONTINUE READING

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