Changes of serum growth factors (IGF-I & IGFBP-2) and prediction of response to chemotherapy in patients with acute myeloid leukemia.

@article{ElNaggar2008ChangesOS,
  title={Changes of serum growth factors (IGF-I & IGFBP-2) and prediction of response to chemotherapy in patients with acute myeloid leukemia.},
  author={Amel A El-Naggar and Bothaina F. Mahmoud and Lobna A Abou Shamaa and Mona A Salama},
  journal={The Egyptian journal of immunology},
  year={2008},
  volume={15 2},
  pages={
          73-80
        }
}
Insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) possess mitogenic properties promoting cellular proliferation and inhibiting cellular apoptosis. Thus, IGF-system may play a role in tumor proliferation. In the present study, we investigated IGF-I and IGFBP-2 in patients with acute myeloid leukemia (AML) for their predictive value to identify patients who could be responsive to conventional induction chemotherapy. Serum levels of IGF-I and IGFBP-2 were measured (using… CONTINUE READING

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