Changes of peripheral A2A adenosine receptors in chronic heart failure and cardiac transplantation.

@article{Varani2003ChangesOP,
  title={Changes of peripheral A2A adenosine receptors in chronic heart failure and cardiac transplantation.},
  author={Katia Varani and Franco Laghi-Pasini and Alessandra Camurri and Pier Leopoldo Capecchi and Massimo Maccherini and Francesco Diciolla and Linda Ceccatelli and Pietro Enea Lazzerini and Canan Ulouglu and Flaminio Cattabeni and Pier Andrea Borea and Maria P. Abbracchio},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2003},
  volume={17 2},
  pages={280-2}
}
Peripheral blood mononuclear cells of chronic heart failure (CHF) patients produce great amounts of pro-inflammatory cytokines, indicating that circulating cells are activated and could mirror changes occurring in inflammatory cells infiltrating the failing heart. Adenosine is a regulatory metabolite acting through four membrane receptors that are linked to adenylyl cyclase: activation of the A2A receptor subtype has been reported to inhibit cytokine release. Changes of the adenosinergic system… CONTINUE READING