Changes of microRNA profile and microRNA-mRNA regulatory network in bones of ovariectomized mice.

@article{An2014ChangesOM,
  title={Changes of microRNA profile and microRNA-mRNA regulatory network in bones of ovariectomized mice.},
  author={Jee Hyun An and Jung Hun Ohn and Jung Ah Song and J Yang and Hyo Jung Park and Hyung Jin Choi and Sang Wan Kim and Woog-Yang Park and Chan Soo Shin},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2014},
  volume={29 3},
  pages={644-56}
}
Growing evidence shows the possibility of a role of microRNAs (miRNA) in regulating bone mass. We investigated the change of miRNAs and mRNA expression profiles in bone tissue in an ovariectomized mice model and evaluated the regulatory mechanism of bone mass mediated by miRNAs in an estrogen-deficiency state. Eight-week-old female C3H/HeJ mice underwent ovariectomy (OVX) or sham operation (Sham-op), and their femur and tibia were harvested to extract total bone RNAs after 4 weeks for… CONTINUE READING