Changes of meningeal excitability mediated by corticotrigeminal networks: a link for the endogenous modulation of migraine pain.

@article{Noseda2010ChangesOM,
  title={Changes of meningeal excitability mediated by corticotrigeminal networks: a link for the endogenous modulation of migraine pain.},
  author={Rodrigo Noseda and Lu{\'i}s Constandil and Laurence Bourgeais and Maryse Chalus and Luis H Villanueva},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 43},
  pages={14420-9}
}
Alterations in cortical excitability are implicated in the pathophysiology of migraine. However, the relationship between cortical spreading depression (CSD) and headache has not been fully elucidated. We aimed to identify the corticofugal networks that directly influence meningeal nociception in the brainstem trigeminocervical complex (Sp5C) of the rat. Cortical areas projecting to the brainstem were first identified by retrograde tracing from Sp5C areas that receive direct meningeal inputs… CONTINUE READING

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