Changes of insulinemia, glycemia and feeding behavior induced by VMH-procainization in the rat

@article{Berthoud1979ChangesOI,
  title={Changes of insulinemia, glycemia and feeding behavior induced by VMH-procainization in the rat},
  author={Hans-Rudolf Berthoud and Bernard Jeanrenaud},
  journal={Brain Research},
  year={1979},
  volume={174},
  pages={184-187}
}
An excitatory ventromedial hypothalamus to paraventricular thalamus circuit that suppresses food intake
TLDR
A neural circuit from VMH to PVT that inhibits food intake is revealed and it is found that activation of SF1 neurons or their projections to the PVT elicits a flavor aversive effect, and selective optogenetic stimulation of ChR2-expressing SF1 projections toThe PVT elicit direct excitatory postsynaptic currents.
Hypothalamic Pituitary Adenylate Cyclase-Activating Polypeptide: Impact On Energy Homeostasis And Glutamate Signaling
TLDR
The results of the studies involving PACAP-mediated modulation of glutamate neurotransmission indicate that PACAP affects glutamatergic signaling in multiple ways, however, modulation of NMDA receptor activity in the hypothalamus may be the primary mechanism for the regulation of food intake.
Effect of Procainization of Ventromedial Nucleus of Hypothalamus on the Feeding Behavior of Rats
TLDR
The results suggest that bilateral procainization of VMH produces a transient increase in food intake and enhance preference for sweet tasting substances.
Deep brain stimulation for obesity in the normal non human primate: A preclinical approach.
TLDR
It is concluded that stimulating the VMH region throughout an Intraventricular approach might modulate acutely food ingestion and induce a sustained decrease in weight and in fat content in normal non obese human primates.
The integrative role of CNS fuel-sensing mechanisms in energy balance and glucose regulation.
TLDR
It is proposed that the central nervous system responds to peripheral signals to orchestrate changes in both energy and glucose homeostasis and dysfunction of the ability of the CNS to integrate fuel-sensing signals may underlie the etiology of metabolic diseases such as obesity and diabetes.
Neural pathways involved in the hypothalamic integration of autonomic responses
TLDR
Evidence supports the idea that the hypothalamic areas involved in the control of ingestion and metabolism form the rostral pole of a longitudinally and hierarchically organized system that elaborates autonomic responses that influence the energy economy of the animal.
The role of hyperinsulinema and the vagus nerve in hypothalamic hyperphagia reexamined
TLDR
It is revealed that subdiaphragmatic vagotomy completely blocks VMH hyperphagia and obesity on a chow diet, but does not prevent overeating and rapid weight gain in rats fed an assortment of highly palatable foods.
Current and potential drugs for treatment of obesity.
TLDR
The objective of this study was to evaluate the effectiveness of antiobesity treatment against a broad range of drugs that alter metabolism, including thyroid hormone, adrenergic thermogenic drugs, and drugs that increase energy expenditure.
...
1
2
...

References

SHOWING 1-10 OF 11 REFERENCES
Acute hyperinsulinemia and its reversal by vagotomy after lesions of the ventromedial hypothalamus in anesthetized rats.
TLDR
It is concluded that electrolytic VMH destruction causes immediate hypersecretion of the pancreatic B cell, an effect that requires the integrity of the vagus nerves.
Ventromedial hypothalamus modulates fat mobilisation during fasting
TLDR
It is reported here that unilateral abdominal sympathectomy or an ipsilateral ventromedial hypothalamus lesion impairs lipolysis during fasting but that a lateral hypothalamic lesion is without effect.
Consequences of ventromedial hypothalamic lesions on metabolism of perfused rat liver.
TLDR
After treatment with anti-insulin serum, the high rate of lipogenesis observed in livers from VMH-lesioned rats was restored toward normal, and it is suggested that hyperinsulinemia may be partly responsible for the metabolic disorders observed inLivers from nonhyperphagic VMH -lesioned Rats.
Effect of transplantation of pancreas on development of hypothalamic obesity
TLDR
The aim of the present experiment was to distinguish between these possibilities by freeing the insulin-secreting islets of Langerhans from neural control, and implanting foetal pancreatic tissue under the kidney capsule of diabetic rats, which prevented the characteristic hyperphagia and obesity seen in the control animals with normally innervated pancreatics tissue.
Effect of ventromedial hypothalamic procaine injections on feeding, lever pressing, and other behavior in rats.
  • R. Larkin
  • Biology, Psychology
    Journal of comparative and physiological psychology
  • 1975
Rats were given bilateral injections of 1-2 mul procaine HCl solution (50 mug/mul) in the region of the ventromedial hypothalamus. Normal-sized meals occurred reliably with a latency of 16-120 sec,
Insulin and Growth Hormone Secretion in Rats with Ventromedial Hypothalamic Lesions Maintained on Restricted Food Intake
TLDR
It is indicated that VMH lesions per se enhance the responsiveness of the pancreatic islets to insulin secretory stimulation independent of changes in food intake, meal size and meal frequency.
Increased feeding in response to decreased glucose utilization in the rat and monkey.
TLDR
Since Z-DG produced marked hyperglycemia during the period of increased feeding, these results show that the abrupt onset of decreased glucose utilization, not hypoglycemia, is a sufficient condition for feeding in mammals.
...
1
2
...