Changes of fractional renal clearance of magnesium after spironolactone administration in normal subjects

@article{Mountokalakis2005ChangesOF,
  title={Changes of fractional renal clearance of magnesium after spironolactone administration in normal subjects},
  author={Th. Mountokalakis and George Merikas and P. Skopelitis and Markos Vardakis and Nikolaos Sevastos and John G. Alivisatos},
  journal={Klinische Wochenschrift},
  year={2005},
  volume={53},
  pages={633-635}
}
ZusammenfassungSpironolactone wurde in Dosen von 200 mg/Tag über eine Zeitspanne von 4 Tagen an 18 klinisch Gesunde und 10 stationäre Patienten mit normaler Nierenfunktion verabreicht. Bei den Gesunden wurden Änderungen des Magnesiumanteils der renalen Clearance vor und nach der Verabreichung von Spironolacton untersucht. Bei den stationären Patienten untersuchte man entsprechende Änderungen des Verhältnisses der renalen Kalium-Clearance zur renalen Magnesium-Clearance. Nach Verabreichung von… 
1 Citations
Effects of Diuretics on the Renal Handling of Magnesium
TLDR
A dose-response relationship has been established for the effect of amiloride in reducing fractional excretion of magnesium and potassium during frusemide diuresis in rats, and further studies are required to establish the precise mechanism(s) involved in the drug's magnesium-sparing properties.

References

SHOWING 1-10 OF 16 REFERENCES
Nebennierenrinde und Magnesiumstoffwechsel
ZusammenfassungDie Mitteilung befaßt sich mit dem Einfluß der Nebennierenrinden-Hormone auf den Magnesiumstoffwechsel.1. Bei Kranken mit Hyperkortizismus vom Cushing-Typ war die Magnesiumausscheidung
Das Verhalten des Serum-Magnesiums bei experimenteller Hyperthyreose und bei gleichzeitiger Anwendung eines Aldosteron-Antagonisten
TLDR
It is shown that an aldosterone antagonist prevents the lowering of the serum magnesium level which can be observed in experimental hyperthyroidism.
Effect of aldosterone on the metabolism of magnesium.
TLDR
It is suggested that aldosterone increases the clearance and excretion of magnesium and potassium in a parallel manner in patients with primary aldosteronism and in an adrenalectomized subject.
Stop Flow Analysis of Aldosterone and Steroidal Antagonist SC-8109 on Renal Tubular Sodium Transport Kinetics.∗
  • A. Vander, W. Wilde, R. Malvin
  • Biology, Medicine
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1960
TLDR
Aldosterone when given to adrenalectomized dogs did not alter proximal Na reabsorption, as this can be estimated by stop flow data, and adrenalectomy reduces maximal Na concentration gradient which can be maintained across distal tubular cells.
Studies of the acute effects of aldosterone and cortisol on the interrelationship between renal sodium, calcium and magnesium excretion in normal man.
TLDR
It is concluded that aldosterone and cortisol have no direct effect on renal tubular reabsorption of calcium or magnesium.
Is magnesium secreted by the rat renal tubule?
TLDR
It is concluded that tubular secretion of magnesium does not occur in the rat under these condition, even during sulfate infusion, when a distal secretory peak of potassium occurred.
DEVELOPMENT OF METHODS FOR THE DETERMINATION OF MAGNESIUM
  • N. Alcock
  • Chemistry
    Annals of the New York Academy of Sciences
  • 1969
TLDR
The difficulties encountered in chemical methods frequently used in estimating magnesium are related to the basic principles of the techniques and the precision and sensitivity of recommended methods are tabulated.
Serum magnesium in children with cirrhosis.
...
...