Changes of cholinesterase activities in the rat blood and brain after sarin intoxication pretreated with butyrylcholinesterase.

@article{Bajgar2007ChangesOC,
  title={Changes of cholinesterase activities in the rat blood and brain after sarin intoxication pretreated with butyrylcholinesterase.},
  author={Jiř{\'i} Bajgar and L. Bartosov{\'a} and Kamil Ku{\vc}a and Daniel Jun and Josef Fusek},
  journal={Drug and chemical toxicology},
  year={2007},
  volume={30 4},
  pages={351-9}
}
After sarin inhalation exposure of rats pretreated with equine serum butyrylcholinesterase (EqBuChE), cholinesterase activities of the whole blood, acetylcholinesterase (AChE) in erythrocytes, pontomedullar area, frontal cortex, and striatum of the brain, and plasma butyrylcholinesterase (BuChE) were determined. Using different doses of EqBuChE as a pretreatment (intraperitoneal injection), dose-dependent increases in plasma BuChE activity and no changes in the erythrocyte and brain AChE… CONTINUE READING