Changes of cerebral blood flow during the secondary expansion of a cortical contusion assessed by 14C-iodoantipyrine autoradiography in mice using a non-invasive protocol.

@article{Engel2008ChangesOC,
  title={Changes of cerebral blood flow during the secondary expansion of a cortical contusion assessed by 14C-iodoantipyrine autoradiography in mice using a non-invasive protocol.},
  author={Doortje C. Engel and G{\"u}nter Mies and Nicole Angela Terpolilli and Raimund Trabold and Alexander Loch and Chris I. De Zeeuw and John T. Weber and Andrew I. R. Maas and Nikolaus Plesnila},
  journal={Journal of neurotrauma},
  year={2008},
  volume={25 7},
  pages={
          739-53
        }
}
Although changes of cerebral blood flow (CBF) in and around traumatic contusions are well documented, the role of CBF for the delayed death of neuronal cells in the traumatic penumbra ultimately resulting in secondary contusion expansion remains unclear. The aim of the current study was therefore to investigate the relationship between changes of CBF and progressive peri-contusional cell death following traumatic brain injury (TBI). CBF and contusion size were measured in C57Bl6 mice under… 

Temporal profile of thrombogenesis in the cerebral microcirculation after traumatic brain injury in mice.

The current data suggest that the immediate post-traumatic decrease in peri-contusional blood flow is not caused by arteriolar vasoconstriction, but by platelet activation and the subsequent formation of thrombi in the cerebral microcirculation.

Temporal Dynamics of Cerebral Blood Flow, Cortical Damage, Apoptosis, Astrocyte–Vasculature Interaction and Astrogliosis in the Pericontusional Region after Traumatic Brain Injury

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Key role of sulfonylurea receptor 1 in progressive secondary hemorrhage after brain contusion.

These findings provide novel insights into molecular mechanisms responsible for PSH associated with hemorrhagic contusions, and point to SUR1 as a potential therapeutic target in TBI.

Mild traumatic brain injury results in depressed cerebral glucose uptake: An (18)FDG PET study.

It is shown that mild TBI, which is characterized by transient impairments in function, axonal damage, and glial activation, results in an observable depression in overall brain glucose uptake using (18)FDG-PET.

Rheological effects of drag-reducing polymers improve cerebral blood flow and oxygenation after traumatic brain injury in rats

  • D. BraginM. Kameneva E. Nemoto
  • Biology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2017
After TBI, nanomolar concentrations of intravascular DRP significantly enhanced microvascular perfusion and tissue oxygenation in peri-contusional areas, preserved blood–brain barrier integrity and protected neurons.

Hemorrhagic progression of a contusion after traumatic brain injury: a review.

The topic of HPC is reviewed, data relevant to the concept of a coagulopathy is examined, and emerging data elucidating the mechanism of progressive microvascular failure that predisposes to HPC after head trauma are detailed.

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