Changes of cerebral blood flow during the secondary expansion of a cortical contusion assessed by 14C-iodoantipyrine autoradiography in mice using a non-invasive protocol.

  title={Changes of cerebral blood flow during the secondary expansion of a cortical contusion assessed by 14C-iodoantipyrine autoradiography in mice using a non-invasive protocol.},
  author={Doortje C. Engel and G{\"u}nter Mies and Nicole Angela Terpolilli and Raimund Trabold and Alexander Loch and Chris I. De Zeeuw and John T. Weber and Andrew I. R. Maas and Nikolaus Plesnila},
  journal={Journal of neurotrauma},
  volume={25 7},
Although changes of cerebral blood flow (CBF) in and around traumatic contusions are well documented, the role of CBF for the delayed death of neuronal cells in the traumatic penumbra ultimately resulting in secondary contusion expansion remains unclear. The aim of the current study was therefore to investigate the relationship between changes of CBF and progressive peri-contusional cell death following traumatic brain injury (TBI). CBF and contusion size were measured in C57Bl6 mice under… 

Temporal profile of thrombogenesis in the cerebral microcirculation after traumatic brain injury in mice.

The current data suggest that the immediate post-traumatic decrease in peri-contusional blood flow is not caused by arteriolar vasoconstriction, but by platelet activation and the subsequent formation of thrombi in the cerebral microcirculation.

Temporal Dynamics of Cerebral Blood Flow, Cortical Damage, Apoptosis, Astrocyte–Vasculature Interaction and Astrogliosis in the Pericontusional Region after Traumatic Brain Injury

Results suggest that TBI results in a progression from acute neurodegeneration that precedes astrocytic activation, reformation of the neurovascular unit to glial scar formation, which is critical to the ability to develop neuroprotective therapeutics to ameliorate the short and long-term consequences of brain injury.

In vivo temporal and spatial profile of leukocyte adhesion and migration after experimental traumatic brain injury in mice

It is suggested that neither intravascular leukocyte adhesion nor the migration of leukocytes into cerebral tissue play a significant role in the development of secondary lesion expansion following TBI.

Key role of sulfonylurea receptor 1 in progressive secondary hemorrhage after brain contusion.

These findings provide novel insights into molecular mechanisms responsible for PSH associated with hemorrhagic contusions, and point to SUR1 as a potential therapeutic target in TBI.

Mild traumatic brain injury results in depressed cerebral glucose uptake: An (18)FDG PET study.

It is shown that mild TBI, which is characterized by transient impairments in function, axonal damage, and glial activation, results in an observable depression in overall brain glucose uptake using (18)FDG-PET.

Rheological effects of drag-reducing polymers improve cerebral blood flow and oxygenation after traumatic brain injury in rats

  • D. BraginM. Kameneva E. Nemoto
  • Biology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2017
After TBI, nanomolar concentrations of intravascular DRP significantly enhanced microvascular perfusion and tissue oxygenation in peri-contusional areas, preserved blood–brain barrier integrity and protected neurons.

Hemorrhagic progression of a contusion after traumatic brain injury: a review.

The topic of HPC is reviewed, data relevant to the concept of a coagulopathy is examined, and emerging data elucidating the mechanism of progressive microvascular failure that predisposes to HPC after head trauma are detailed.



Continuous measurement of changes in regional cerebral blood flow following cortical compression contusion trauma in the rat.

It is tentatively concluded that the posttraumatic hypoperfusion phase was similar within the trauma region, and proposed that CSD, known to occur on the ipsilateral side in this model, is one of the factors involved in acute blood flow decreases seen following cerebral trauma.

Severe controlled cortical impact in rats: assessment of cerebral edema, blood flow, and contusion volume.

T2-weighted MRI successfully and noninvasively identifies contusion volume in this model of controlled cortical impact in rats and indicates that severe CCI in rats is accompanied by contusion, reproducible edema, and marked hypoperfusion.

Effects of Traumatic Brain Injury on Regional Cerebral Blood Flow in Rats as Measured with Radiolabeled Microspheres

  • I. YamakamiT. Mcintosh
  • Biology, Medicine
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 1989
It is demonstrated that acute changes in r CBF occur following experimental traumatic brain injury in rats and that rCBF remains significantly depressed up to 2 h post injury in the area circumscribing the trauma site.

Focal ischemia due to traumatic contusions documented by stable xenon-CT and ultrastructural studies.

Data support the conclusion that microvascular compromise by compression and/or occlusion is a major event associated with profound perilesional hypoperfusion, which is a uniform finding within edematous pericontusional tissue.

Responses of Posttraumatic Pericontusional Cerebral Blood Flow and Blood Volume to an Increase in Cerebral Perfusion Pressure

  • L. SteinerJ. Coles J. Pickard
  • Medicine
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2003
Pericontusional oedema on computed tomography was associated with lower absolute values of CBF and CBV but did not differ from nonoedematous tissue in the relative response to CPP elevation.

Early perfusion after controlled cortical impact in rats: Quantification by arterial spin‐labeled MRI and the influence of spin‐lattice relaxation time heterogeneity

This is the first report of cerebral blood flow measurement by continuous arterial spin‐labeled magnetic resonance imaging (MRI) early after TBI in rats using the controlled cortical impact (CCI) model, and MRI should facilitate coupling posttraumatic CBF with long‐term functional outcome.

Posttraumatic cerebral ischemia after fluid percussion brain injury: an autoradiographic and histopathological study in rats.

Data indicate that multiple cerebrovascular abnormalities, including subarachnoid hemorrhage, focal platelet accumulation, and severe ischemia, are important early events in the pathogenesis of cortical contusion formation after TBI.

Regional Cerebral Blood Flow After Controlled Cortical Impact Injury in Rats

It is concluded that complex changes in rCBF occur shortly after CCII and persist for at least 4 h, during which time several brain regions, especially the cortical areas, may suffer damage due to the ischemia.

The effects of traumatic brain injury on regional cerebral blood flow in rats.

In rats, the most prominent cerebral circulatory changes following fluid percussion injury were early reductions of CBF and an increasingly heterogeneous CBF pattern and the traumatized group exhibited heterogeneous decreases in CBF following trauma.

Blood Flow and Ischemia within Traumatic Cerebral Contusions

The isChemic profile of the contusions, with a pericontusional zone of low rCBF, presents the potential risk of secondary ischemic insults, similar to the risk in the ischemi penumbral zones surrounding areas of acute ischeMIC stroke.